Monga chonyamulira chofunikira pakupanga mankhwala amakono,enteric-zokutidwamakapisoziamagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala chifukwa cha ubwino wake, monga malo enieni-kutulutsidwa kwapadera, kuteteza mankhwala kuti asawonongeke ndi asidi wa m'mimba, komanso kuteteza mankhwala kuti asakwiyitse mucosa ya m'mimba. Komabe, panthawi yopanga ndi kusungirako zenizeni, nthawi yowonongeka kwa ma capsules a enteric nthawi zambiri ndi chizindikiro cha khalidwe lofunika kwambiri lomwe ndi lovuta kulamulira. Kuchedwa kupatukana kapena kumasulidwa msanga kumakhudza mwachindunji bioavailability ndi chithandizo chamankhwala chamankhwala. Nanga, ndi zinthu ziti zomwe zimakhudza kuwonongeka kwa ma enteric-makapisozi opaka?
Choyamba, mapangidwe ndi katundu wa zipolopolo ndizo zinthu zofunika kwambiri zomwe zimazindikiritsa ntchito ya kupasuka.Makapisozi a Enterickawirikawiri ntchitogelatinmonga maziko, ophatikizidwa ndi ma polima a enteric monga ma acrylic resins, cellulose acetate phthalate (CAP), kapena shellac. Kusungunuka kwa zinthu za enteric izi kumadalira pH mtengo wa m'matumbo. Ngati chiŵerengero cha zinthu zomatira ndi zosayenera-mwachitsanzo, ngati kuchuluka kwa filimu-kuchuluka kwambiri-kungachititse kuti chipolopolocho chitha kusungunuka kapena kukokoloka mofulumira m'matumbo, zomwe zimachititsa kuti filimuyo isaphatikizidwe kupitirira nthawi. Kuphatikiza apo, kulimba kwa maluwa a gelatin, kukhuthala kwake, komanso kuchuluka kwa -kulumikizana kolumikizana kumakhudzanso mayamwidwe ndi kufalikira kwa chigoba cha kapisozi.
Chachiwiri,njira zopangirandipo zosungirako zimagwira ntchito yofunika kwambiri. Mu kapisozi akamaumba ndondomeko, kulamulira kuyanika kutentha ndi nthawi n'kofunika kwambiri. Kuyanika kwambiri kungayambitse chinyezi chochepa kwambiri mu chipolopolocho, ndikupangitsa kuti chikhale cholimba komanso cholimba, chomwe chimakhudza kunyowa kwake ndi kulowa kwake ndi madzi a m'thupi; Mosiyana ndi zimenezi, chinyezi chambiri chingapangitse kuti chipolopolocho chifewetse kapena kupunduka. Chochititsa chidwi kwambiri ndi chakuti chinyezi, kutentha, ndi kuwala mumalo osungiraikhoza kuyambitsa "mtanda-kulumikizana" mu gelatin. Mtandawu-wolumikizana nawo umapanga madzi-opanda kusungunuka pa netiweki pamwamba pa chipolopolo, zomwe zimapangitsa kapisozi kulephera kuyamwa madzi ndi kupasuka mwachizolowezi atalowa m'thupi la munthu, zomwe zimadziwika kuti "insolubility".
Pomaliza, katundu wa zinthu zodzaza sangathe kunyalanyazidwa. Ngakhale kupatukana kumayang'ana kwambiri chipolopolo, chikoka cha zomwe zili mkati ndizoonadi. Ngati mankhwalawa ali ndi acidity yamphamvu kapena alkalinity, kapena ali ndi ma aldehydes ambiri, amatha kufulumizitsa kusintha kwamankhwala ndi zipolopolo, ndikusokoneza kukhazikika kwa gawo la enteric. Izi zingayambitse kuphulika msanga m'mimba kapena kulepheretsa kutuluka kwachibadwa m'matumbo a m'mimba.
Mwachidule, zinthu zomwe zimakhudza kupasuka kwa ma capsules opanda kanthu a enteric ndizinthu zambiri, kuphatikizapo mankhwala azinthu zopangira, kulamulira kwa magawo opanga, komanso kukhazikika kwa malo osungira. Makampani opanga mankhwala amayenera kuwongolera mosamalitsa mtundu wazinthu zopangira, kukhathamiritsa njira zowumitsa, ndikuwonetsetsa kuti malo osungirako ozizira komanso owuma. Pokhapokha poyang'anira zinthu zonsezi m'mene tingathe kuwonetsetsa kuti enteric-makapisozi okutidwa aphwasuka ndikutuluka m'thupi moyenera komanso moyenera, zomwe zimatsimikizira kuti mankhwalawa ali ndi mphamvu.
