Monga Zovala za mankhwala, khalidwe la makapisozi opanda kanthu limatsimikizira mwachindunji chitetezo, mphamvu, ndi kukhazikika kwa mankhwala omaliza. Ngati zipolopolo za kapisozi zooneka ngati zosavuta zimakhala ndi zolakwika musanadzazidwe ndi mankhwala, zikhoza kukhala zoopsa zobisika ku khalidwe la mankhwala. Zowonongeka izi sizimachokera ku njira zopatuka panthawi yopanga komanso zimagwirizana kwambiri ndi kusawongolera bwino kwa chilengedwe panthawi yosungira ndi kunyamula. Atha kugawidwa m'magulu atatu akuluakulu: thupi, mankhwala, ndi biological.
Zowonongeka zakuthupi ndizodziwika bwino komanso zofala kwambiri. Choyamba ndi Fragility kapena Brittleness. Chigoba cha capsule choyenerera chiyenera kukhala ndi elasticity ndi kulimba kwapakati. Kapisozi wa brittle amakonda kusweka panthawi yoyendetsa kapena kudzaza, zomwe zimatsogolera kutayikira kwa mankhwala ndi dosing molakwika. Chotsatira ndi Makulidwe Osafanana kapena Mapiritsi a Air, omwe amatha kusokoneza kuchuluka kwa kapisozi, zomwe zitha kupangitsa kuti mankhwalawa atulutsidwe mwachangu kapena pang'onopang'ono m'thupi, motero amakhudza machiritso ake. Kuphatikiza apo, Dimensional Deviation ndi nkhani yayikulu yopanga. Ngati miyeso ya kapu ndi thupi sizikugwirizana bwino, zimabweretsa chisindikizo chosauka, chomwe chimawapangitsa kuti azilekanitsa mosavuta panthawi yosungiramo ndikuwonetsa mankhwala ku chilengedwe, zomwe zimayambitsa kuwonongeka. Kupanda ungwiro kwapamtunda monga Zokwapula, Mawanga, kapena Kutuluka kwamitundu sizinthu zokongola zokha; amathanso kukhala zizindikiro za zinthu zodetsedwa kapena kuipitsidwa panthawi yopanga.
Kuwonongeka kwa mankhwala kumakhala kosawoneka bwino koma koopsa kwambiri. Mfundo yaikulu ya nkhaniyi ili mu khalidwe la gelatin. Ngati zinthu zotsika mtengo, monga-zopanda mankhwala-zokhala ndi gelatin, zitagwiritsidwa ntchito, kapena ngati zinthu zovulaza zayambika panthawi yopanga, zipolopolo za makapisozi zimatha kukhala ndi zitsulo zolemera kwambiri (monga chromium), otsalira a titanium dioxide, kapena zosungunulira zowononga zachilengedwe. Mankhwalawa amatha kudziunjikira m'thupi la munthu pakapita nthawi, kuwononga ziwalo monga chiwindi ndi impso. Chochitika cha Toxic Capsule chomwe chinadabwitsa dzikolo zaka zingapo zapitazo chinali chotsatira chachindunji cha kugwiritsa ntchito gelatin yamakampani, zomwe zidapangitsa kuti chromium yolemera kwambiri ikhale pachiwopsezo chachikulu ku thanzi la anthu. Kuonjezera apo, ngati pH mtengo wa chipolopolo cha kapisozi sichikukwanira, ukhoza kuchitapo kanthu ndi mankhwala ena amchere kapena acidic, kuwapangitsa kuti awonongeke kapena kupanga zinthu zovulaza.
Kuwonongeka kwachilengedwe kumatanthawuza kuipitsidwa ndi tizilombo tating'onoting'ono. Olemera mu mapuloteni ndi chinyezi, makapisozi opanda kanthu ndi njira yabwino kwambiri yopangira tizilombo toyambitsa matenda. Ngati ukhondo wa malo opangirako ndi wocheperapo kapena ngati malo osungiramo ndi onyowa kwambiri, zipolopolo za kapisozi zimatha kuipitsidwa mosavuta ndi mabakiteriya, nkhungu, ngakhale tizilombo toyambitsa matenda. Makapisozi opanda kanthu omwe ali ndi tizilombo toyambitsa matenda samangowononga mankhwala, zomwe zimatha kuyambitsa matenda am'mimba kapena ziwengo kwa odwala, komanso kagayidwe kawo ka kagayidwe kake (monga mycotoxins) nakonso kumayambitsa khansa. Chifukwa chake, kuyesa kokhazikika kwa ma microbial malire pa makapisozi opanda kanthu ndi gawo lofunikira pakuwongolera khalidwe.
Pomaliza, zofooka za makapisozi opanda kanthu sizikhala nkhani yosavuta yowoneka bwino. Kuchokera pa kukhulupirika kwa thupi ndi chiyero cha mankhwala kupita ku chitetezo chachilengedwe, kuyang'anira kulikonse m'madera awa kungathe kubzala chiwopsezo chobisika. Chifukwa chake, makampani opanga mankhwala amayenera kuwunika mozama ndikuyesa posankha operekera makapisozi opanda kanthu, pomwe mabungwe owongolera ayenera kulimbikitsa kuyang'anira kuti awonetsetse kuti chovala chaching'ono ichi cha Zovala chimakhala ngati chotchinga cholimba chomwe chimateteza thanzi la odwala, m'malo mokhala Bomba la Nthawi ya zoopsa zobisika. Ngati pali mafunso ena okhudza makapisozi opanda kanthu, talandilani ku KornnacCaps.
