M'makampani opanga mankhwala ndi zakudya, makapisozi opanda kanthu amakhala ngati onyamula mankhwala. Ntchito yawo yayikulu sikungophatikiza zomwe zili mkati koma, chofunikira kwambiri, kusweka mwachangu pamalo enaake mkati mwa thupi kuti amasule mankhwalawa. Nthawi yowonongeka imatanthawuza nthawi yofunikira kuti kapsule isinthe kuchoka ku malo olimba kupita kumalo osadziwika bwino; ichi ndi chizindikiro chofunikira choyezera khalidwe la capsule. Chifukwa cha kusiyana kwa kapangidwe ka mankhwala ndi katundu wakuthupi, mitundu yosiyanasiyana ya makapisozi opanda kanthu amawonetsa kusiyana kwakukulu mu malire awo a nthawi ya kupasuka.
Pakadali pano, makapisozi opanda kanthu pamsika amagawidwa kukhala makapisozi a gelatin (anyama-ochokera) ndi masamba (makapisozi a HPMC ndi makapisozi a Pullulan).
Choyamba,makapisozi a gelatinndiwo mawonekedwe apamwamba a mlingo omwe ali ndi mbiri yayitali kwambiri. Chigawo chawo chachikulu chimachokera ku khungu la nyama ndi mafupa a collagen, omwe ali ndi hydrophilicity yabwino kwambiri. M'malo abwinobwino am'mimba yamadzimadzi (madigiri 37, sing'anga yamadzi), makapisozi a gelatin amamwa madzi ndikumakula mwachangu, chipolopolocho chimafewetsa ndikusungunuka mwachangu. Malinga ndi Chinese Pharmacopoeia ndi miyezo yoyenera, nthawi yolekanitsidwa ya makapisozi a gelatin nthawi zambiri imayenera kukhala mkati mwa mphindi 30. Chifukwa chakusungunuka kwawo m'madzi-kusungunuka, makapisozi a gelatin amayambika mwachangu ndipo ndi omwe amawakonda pamankhwala ambiri wamba.
Chachiwiri,HPMC makapisozindiwo omwe amagwiritsidwa ntchito kwambiri ndi makapisozi amasamba. Mosiyana ndi gelatin, HPMC ndi chochokera ku cellulose chokhala ndi mawonekedwe okhazikika a mankhwala. Makina a HPMC kapisozi kusungunuka m'madzi ali ndi mgwirizano wochepa ndi kutentha ndipo samakhudzidwa kwambiri ndi pH mtengo. Ngakhale malire awo a nthawi ya kupasuka amagwirizananso ndi kufunikira kwa pharmacopoeia mkati mwa mphindi za 30, makapisozi a HPMC nthawi zambiri amawonetsa kukhazikika kwapang'onopang'ono panthawi yakutha. Makamaka m'malo otsika-kutentha kapena{6}}kwachinyezi chapamwamba, makapisozi a HPMC amasunga kulimba ndi kusungunuka kwabwino; samavutika ndi kusweka kwa nthawi yayitali chifukwa cha-kusokonekera kolumikizana (ukalamba) monga momwe makapisozi a gelatin amachitira nthawi zina.
Kuphatikiza apo, pazosowa zapadera, pali ma enteric-makapisozi okutidwa ndi makapisozi okhazikika-otulutsidwa. Mosasamala kanthu kuti matrix ndi gelatin kapena fiber fiber, enteric-makapisozi okutidwa amasinthidwa mwapadera kapena kusinthidwa mankhwala. Iwo samasweka mu chikhalidwe cha asidi chapamimba ndipo amangosungunuka atalowa m'malo enieni a pH a m'matumbo. Nthawi yawo yowonongeka nthawi zambiri imayenera kukhala mkati mwa ola la 1 mumadzimadzi a m'matumbo opangira, omwe amakhala pansi pa gulu la kumasulidwa koyendetsedwa.
Mwachidule, makapisozi wamba a gelatin ndi makapisozi a masamba ali ndi malire a nthawi yofananira (onse mkati mwa mphindi 30), koma makapisozi amasamba amachita bwino pokhazikika pansi pazikhalidwe zowopsa komanso kukana kukalamba. Posankha mitundu ya makapisozi, makampani opanga mankhwala amayenera kuganizira mozama za mankhwala, momwe amasungirako, komanso zofunikira zenizeni pakutha kwachangu kuonetsetsa kuti mankhwalawa ali ndi bioavailability.
