Monga chonyamulira chofunikira pakupanga mankhwala amakono, kusinthika kwa makapisozi olimba opanda kanthu kumawonetsa kupita patsogolo kwamankhwala kuchokera kuchikhalidwe kupita kumayendedwe amakono. Wothandizira mankhwala wooneka ngati wosavuta samangoyang'ana nkhani monga kuwawa ndi kukwiya kwa mankhwala panthawi ya utsogoleri komanso wathandizira kukhazikika ndi kukula kwa makampani opanga mankhwala, kukhala gawo lofunika kwambiri pamitundu ya mlingo wa mankhwala.
Kapisozi wa makapisozi amatha kutengera ku Egypt ndi Greece wakale, komwe anthu amagwiritsa ntchito matumbo anyama kapena sera kukulunga mankhwala kuti aphimbe fungo losasangalatsa kapena kumeza. Komabe, kapisozi weniweni wopanda kanthu adabadwa chapakati pazaka za m'ma 1900 ku France. Mu 1834, katswiri wazamankhwala waku Paris Achille Colas adapanga njira yopangira makapisozi a gelatin pamanja poviika nkhungu kuti apange zipolopolo za kapisozi, kukwaniritsa kukhazikika kwa mankhwala kwanthawi yoyamba. Kutulukira kumeneku kunafalikira mofulumira ku Ulaya konse ndipo kunafika ku United States chakumapeto kwa zaka za m’ma 1800, zomwe zinachititsa kuti mafakitale ayambe kupanga makapisozi.
Kumayambiriro kwa zaka za m'ma 1900, ndikukula kwa makampani opanga mankhwala, teknoloji yopangira makapisozi olimba opanda kanthu inapita patsogolo kwambiri. Mu 1912, katswiri wazamankhwala waku America Robert Paul Scherer adapanga makina opangira kapisozi, omwe amathandizira kupanga mosalekeza ndikuwongolera bwino zonse komanso kusasinthika kwazinthu. Panthawi imeneyi, gelatin inayamba kugwiritsidwa ntchito kwambiri ngati chinthu choyambirira cha kapisozi, ndipo kukula kwa makapisozi kunasinthidwa pang'onopang'ono, kupanga dongosolo lamakono{4}}lomwe limayambira pa 00 mpaka 5.
Pambuyo pa Nkhondo Yachiwiri Yapadziko Lonse, ndikukula kwa msika wapadziko lonse wamankhwala, msika wopanda kanthu wa makapisozi olimba adalowa munthawi yakukula mwachangu. M'zaka za m'ma 1960, kubwera kwa ma enteric-makapisozi okutidwa kunathetsa vuto la mankhwala omwe amawonongeka mosavuta m'mimba. M'zaka za m'ma 1970, makapulisi a masamba adatuluka kuti akwaniritse zosowa za anthu odyetsera zamasamba ndi anthu omwe ali ndi zikhulupiriro zachipembedzo. Pofika m'zaka za m'ma 2100, kugwiritsa ntchito zipangizo zatsopano za polima kwachititsa kuti makapisozi azigwira ntchito bwino, monga-makapisozi otulutsidwa ndi ongoleredwa-kutulutsa makapisozi, zomwe zikupititsa patsogolo zotsatira zachipatala.
Nthawi yomweyo, njira zopangira zidasintha kuchokera ku njira yachikhalidwe yoviika kupita ku njira yabwino kwambiri yogwetsera, kukulitsa luso la kupanga kambirimbiri. Njira zamakono zopangira makapisozi tsopano zili ndi mphamvu zodzichitira zokha, ndipo khalidwe lawo likugwirizana ndi-zovomerezeka zamankhwala. Kupanga makapisozi apachaka padziko lonse lapansi kwapitilira thililiyoni imodzi, pomwe China, United States, ndi Japan ndiwo akutsogola kupanga.
Lero,makapisozi olimba opanda kanthuzasintha kuchokera ku chida chosavuta chotumizira mankhwala kupita ku-kachitidwe kaukadaulo kapamwamba koperekera mankhwala. Sikuti amangokhala ndi zinthu zomwe zimagwira ntchito komanso amaphatikizanso kufunitsitsa kwaumunthu kulondola pakuwongolera mankhwala. Ndi zopambana muukadaulo wosindikizira wa 3D, nanomatadium, ndi zida zoyankhira mwanzeru, makapisozi opanda kanthu olimba ayikidwa kuti awonekere bwino pazamankhwala amunthu payekha, chithandizo cha majini, komanso kuperekera mankhwala omwe akutsata, kupitiliza kulemba mutu wabwino kwambiri pakupititsa patsogolo sayansi yazamankhwala ndiukadaulo. Ngati pali zofunidwa pa makapisozi opanda kanthu, landirani ku KornnacCaps.
