Pankhani ya zamankhwala,enteric-makapisozi okutidwandi mtundu wapadera wa mawonekedwe a mlingo wa mankhwala, ndi chandamale chomveka bwino komanso chofunikira chothetsa - matumbo. Khalidweli limapangitsa kuti ma enteric-makapisozi okutidwa azigwira ntchito yosasinthika popereka mankhwala.
Chifukwa chomwe ma enteric-makapisozi okutidwa amatha kusungunuka m'matumbo zili pakukonzekera kwawo mwapadera. Panthawi yopangira, chipolopolo cha capsule chimakutidwa ndi zokutira zapadera za enteric. Izi zokutira zimakhudzidwa ndi malo acidic komanso amchere. M'malo acidic m'mimba, imatha kukhalabe kukhulupirika kwa kapisozi ndikuletsa kumasulidwa kwamankhwala msanga. M'mimba ndi malo okhala acidic kwambiri okhala ndi pH yamtengo nthawi zambiri pakati pa 1.5 ndi 3.5. Ngati mankhwala wamba amamasulidwa mwachindunji apa, akhoza kuwonongedwa ndi asidi m'mimba, kuchepetsa mphamvu zawo komanso kukwiyitsa mucosa chapamimba, kuchititsa kusapeza bwino. Komabe, kuyaka kwa enteric{8}}makapisozi okutidwa kumakhala kokhazikika m'mimba mwa asidi, kumachita ngati chingwe cholimba choteteza mankhwalawa mkati.
Ma enteric-makapisozi okutidwa akalowetsedwa pamodzi ndi chakudya ndikulowa m'matumbo, zinthu zimasintha. Mtengo wa pH m'matumbo ndi wokwera kwambiri, nthawi zambiri pakati pa 5 ndi 7, pafupi ndi ndale kapena wamchere wofooka. Chilengedwechi chimapangitsa kuti nsabwe za m'mimba ziyambe kusungunuka, ndipo chipolopolo cha capsule pang'onopang'ono chimataya ntchito yake yotetezera, kulola kuti mankhwala mkati mwake amasulidwe. Matumbo si malo ofunikira kuti mayamwidwe a mankhwala alowe komanso malo abwino otulutsirako mankhwala enaake. Mwachitsanzo, mankhwala ena amene amakwiyitsa matumbo a m’mimba, monga aspirin, akatulutsidwa mwachindunji m’mimba, angayambitse kupweteka m’mimba, zilonda zam’mimba, ndi mavuto ena. Powapanga kukhala ma enteric-makapisozi okutidwa, mankhwalawa amatulutsidwa pang'onopang'ono m'matumbo, kuchepetsa kupsa mtima kwa m'mimba ndikuwonetsetsa kuyamwa kokwanira ndi kuchiritsa.
Kuphatikiza apo, kusungunuka bwino kwa ma enteric-makapisozi okutidwa kumathandizanso kuti mankhwalawa akhale ndi bioavailability. Mankhwalawa amatha kutengeka bwino m'matumbo, popewa kuwonongeka kapena kutulutsa m'mimba, potero kuwongolera chithandizo chamankhwala. Mchitidwe wosungunuka m'matumbo a enteric-makapisozi okutidwa ndi nzeru zachipatala ndi luso laukadaulo, kupatsa odwala njira yotetezeka komanso yothandiza kwambiri yamankhwala, zomwe zimapangitsa kuti mankhwalawa afike pamalo omwe akufuna ndikugwiritsa ntchito mphamvu zawo zochizira. Ngati pali funso lokhudza makapisozi opanda kanthu, olandiridwa kuti mulumikizaneKornnacCaps.
